Calcium citrate, a compound known to treat hyperoxaluria and inhibit hyaluronidase release, has been extremely helpful in reducing symptoms. Citrate has a structure similar to oxalate and competes with it in the tissues. In about three months of citrate and diet together, a 70% reduction in can be seen.

Calcium citrate can be irritating if used in excess, and therefore dosages often must be reduced and readjusted. It is recommended that calcium citrate without Vitamin D, two tablets (200mg) taken orally three times a day will neutralize oxalate in the urine. Combining a low oxalate diet and ingestion of calcium oxalate may be most effective for those patients with vulvodynia.